Purevax RCP FeLV is used to vaccinate cats from the age of 8 weeks against the following diseases: • feline viral rhinotracheitis • feline calicivirosis • feline panleucopenia • feline leukaemia
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Availability date: 03/13/2014
What is Purevax RCP FeLV? Purevax RCP FeLV is a vaccine containing the following active substances: • attenuated (weakened) feline rhinotracheitis herpesvirus (FHV F2 strain), • inactivated (killed) calicivirosis antigens (FCV 431 and G1 strains), • attenuated feline panleucopenia virus (PLI IV), • feline leukaemia virus (FeLV) recombinant canarypox virus (vCP97). Purevax RCP FeLV is a lyophilisate (freeze-dried pellet) and solvent that are made up into a suspension for injection. What is Purevax RCP FeLV used for? Purevax RCP FeLV is used to vaccinate cats from the age of 8 weeks against the following diseases: • feline viral rhinotracheitis (a flu-like illness caused by a herpesvirus), • feline calicivirosis (a flu-like illness with inflammation of the mouth caused by a calicivirus), • feline panleucopenia (a serious illness causing bloody diarrhoea caused by a parvovirus), • feline leukaemia (an illness affecting the immune system caused by a retrovirus). The vaccine helps to reduce the symptoms of the diseases and helps to reduce viral excretion in case of calicivirus infection. It can also prevent death due to panleucopenia and prevent FeLV from remaining in the blood. After Purevax RCP FeLV has been made up, 1 ml is injected under the skin. The first injection should be given in cats aged at least eight weeks, with a second injection three to four weeks later. If the cat has high levels of antibodies inherited from the mother, the first vaccination should be delayed until 12 weeks of age. The cat should be revaccinated for all components one year after the first vaccination course, then every year for rhinotracheitis, calicivirosis and feline leukaemia, and every three years for panleucopenia.
How does Purevax RCP FeLV work? Purevax RCP FeLV is a vaccine. Vaccines work by ‘teaching’ the immune system (the body’s natural defences) how to defend itself against diseases. Purevax RCP FeLV contains small amounts of weakened or killed viruses that cause the diseases listed above, as well as two genes from the FeLV called env and gag, which have been inserted into another vector (carrier) virus called canarypox using ‘recombinant DNA technology’. The canarypox viruses do not spread or multiply in the cat but they do produce proteins from the FeLV genes. When a cat is given the vaccine, the immune system recognises the weakened or killed viruses and the FeLV proteins as ‘foreign’ and makes antibodies against them. In the future, the immune system will be able to produce antibodies more quickly when it is again exposed to the viruses. The antibodies will help to protect against the diseases caused by these viruses. When exposed to any of these viruses later in life, the cat will either not become infected or have a much less serious infection. How has Purevax RCP FeLV been studied? The effectiveness of Purevax RCP FeLV has been studied in several trials in laboratory conditions where cats were vaccinated and infected with virulent herpesvirus, calicivirus, parvovirus or leukaemia virus. In the field the studies of Purevax RCP FeLV looked at the basic vaccination schedule (2 injections 3-4 weeks apart) and at the booster vaccination (only one injection). They included young and adult cats of various breeds, but not young kittens. The main measure of effectiveness was the level of antibodies in the blood against the viruses in the vaccine, with the exception of the FeLV component, whose effectiveness in preventing infection had already been demonstrated in other studies. What benefit has Purevax RCP FeLV shown during the studies? In laboratory conditions Purevax RCP FeLV was demonstrated to provide protection against the diseases listed above. In the field study of basic vaccination there was an increase in antibodies against feline rhinotracheitis herpesvirus, calicivirus infection, and feline panleucopenia viruses. In the study looking at booster vaccination, antibody levels against rhinotracheitis herpesvirus, calicivirus infection and feline panleucopenia remained stable at a high level or increased slightly. What is the risk associated with Purevax RCP FeLV? Occasionally, cats will develop temporary apathy (loss of interest in surroundings) and anorexia (loss of appetite), as well as hyperthermia (elevated body temperature) lasting for one or two days. There may be a local reaction at the injection site, with slight pain on touching, itching or oedema (swelling), which disappears within one or two weeks. For a full list of the side-effects reported with Purevax RCP FeLV, see the Package Leaflet. Purevax RCP FeLV should not be used in pregnant cats. What are the precautions for the person who gives the medicine or comes into contact with the animal? In case of accidental self-injection seek medical advice immediately and show the Package Leaflet or the label to the doctor.